David Agard
Professor, Biochemistry & Biophysics
Research summary: Structure, function, and folding of proteins, chromosomes, and centrosomes
Professor, Biochemistry & Biophysics
Research summary: Structure, function, and folding of proteins, chromosomes, and centrosomes
Professor and Chair, Pharmaceutical Chemistry; Co-Director, Small Molecule Discovery Center, Pharmaceutical Chemistry
Research summary: Chemical biology of protein-protein interactions and small-molecule drug discovery using biophysical and biological approaches
Assistant Professor, Urology & Cellular & Molecular Pharmacology
Research summary: We explore the fundamental rules governing antigen presentation and T-cell recognition, chemotherapy mechanisms of action, and cellular senescence.
Professor, Pharmaceutical Chemistry
Research summary: Protein Machines, Posttranslational Dynamics and Mass Spectrometry
Professor, Biochemistry & Biophysics
Research summary: Using molecular electron microscopy as a tool to study structural and functional characterizations of macromolecules assemblies, including endocytotic machinery, clathrin coated vesicles, and protein degradation machinery, proteasome.
Assistant Professor, Medicine
Research summary: Developing chemical and biochemical tools to understand the molecular mechanisms of cardio metabolic disease and develop novel therapies
willow.coyote-maestas@ucsf.edu
Assistant Professor, Bioengineering & Therapeutic Sciences
Research summary: High throughput quantitative approaches for studying membrane proteins folding, function, and trafficking and how mutations tune these processes in evolution and disease. (Students co-mentored by faculty in program.)
Professor, Pharmaceutical Chemistry
Research summary: Protein engineering, mutagenesis, heterologous gene expression, enzyme mechanisms and inhibitor design.
Professor, Pharmaceutical Chemistry
Research summary: Molecular design as an approach to understanding macromolecule structure and function.
Professor, Biochemistry & Biophysics
Research summary: Infectious Disease, Genomics
Professor, Pharmaceutical Chemistry
Research summary: Ion channel structure-function, synaptic plasticity.
Assistant Professor, Radiology & Biomedical Imaging
Research summary: Discovery and application of new biomarkers in oncology with molecular imaging
Professor, Biochemistry & Biophysics
Research summary: Assembly and function of RNA-protein complexes; structure and mechanisms of HIV Tat and Rev; HIV-host protein interactions
Professor, Bioengineering & Therapeutic Sciences
Research summary: Determining how engineering protein conformational ensembles change in response to chemical, physical, and genetic perturbations using structural, computational, and evolutionary approaches
Professor, Cellular & Molecular Pharmacology
Research summary: Chemical approaches to investigate enzymatic function
Professor, Pharmaceutical Chemistry
Research summary: Physical and chemical basis of tissue self-organization and cell-cell interactions
Associate Professor in Residence, Institute for Neurodegenerative Diseases
Research summary: Targeting protein-protein interactions in the molecular chaperone complexes to understand protein homeostasis and treat protein misfolding diseases
Professor, Pharmaceutical Chemistry
Research summary: Structural biology and mechanism of gene specific translation control; RNA turnover; macromolecular NMR spectroscopy.
Professor, Pharmaceutical Chemistry
Research summary: Developing fluorescent probes and optical microscopy techniques for the investigation of genome organization and compartmentalization of cell signaling.
Assistant Professor, Cardiovascular Research Institute
Research summary: Spatial Aspects of Signaling
Professor, Physiology
Research summary: The Molecular Biology of Nociception and Pain
Associate Professor, Otolaryngology
Research summary: Nano-bio science to understand and/or to manipulate biomolecular dynamics at the single molecule level
Associate Professor, Cellular & Molecular Pharmacology
Research summary: Structural basis for Receptor Tyrosine Kinase signaling across the plasma membrane and its regulation by actin cytoskeleton
Associate Professor, Biochemistry & Biophysics
Research summary: We integrate CRISPR-based functional genomics in human iPSC-derived cell types & bioinformatics with mechanistic biochemistry & biophysics to identify disease mechanisms & therapeutic targets. Major areas of interest: Neurodegeneration, protein homeostasis, cell type-specific functions of genes, pathways and organelles.
Professor, Bioengineering & Therapeutic Sciences
Research summary: Computational biology, prediction and design of protein interactions and networks, synthetic biology
Professor, Cellular & Molecular Pharmacology
Research summary: Functional Insights from Genetic and Physical Interaction Maps
Professor, Cellular & Molecular Pharmacology
Research summary: Structure-function studies of potassium channels in mammalian heart and hippocampus.
Assistant Professor, Pharmaceutical Chemistry
Research summary: Molecular basis of transmembrane signaling using integrative techniques in structural biology, biophysics, pharmacology, and protein engineering.
Professor, Cardiovascular Research Institute
Research summary: Molecular Basis of electrical signalling; Ion channel structure, function, and modulation. Membrane protein structure.
Assistant Professor
Research summary: Novel chemical approaches for cancer treatment; challenging drug targets and overcoming therapy resistance; targeted protein degradation and the ubiquitin-proteasome system; organic synthesis.
Sandler Fellow, Asst. Professional Researcher
Research summary: Leverages and develops microfluidic methods to study enzyme function in high throughput.
Professor in Residence, Pharmaceutical Chemistry
Research summary: Small molecule drug discovery; targeted drug delivery; organic synthesis
Professor, Helen Diller Family Endowed Chair in Basic Research, Urology & Cellular & Molecular Pharmacology
Research summary: Systems level understanding of translation control in cancer: Bridging organismal biology, pharmacology & biochemistry
Professor, Bioengineering & Therapeutic Sciences
Research summary: Computation grounded in the laws of physics and evolution to study the structure and function of proteins
Assistant Professor in Residence, Cardiovascular Research Institute
Research summary: Applying modern chemical synthesis to prevailing biological challenges by synthesizing small molecule drug candidates, generating novel chemical libraries, and developing tools to study biological pathways
Professor, Pharmaceutical Chemistry
Research summary: Discovery, design, and synthesis of biologically small molecules and elucidation of their modes of action
Professor, Pharmaceutical Chemistry
Research summary: Molecular docking, structure-based inhibitor discovery, G Protein Coupled Receptors, colloidal aggregation and phospholipidosis in drug discovery and formulation, drug discovery for analgesia and psychiatric disorders.
Professor & Dept. Chair, Cellular & Molecular Pharmacology
Research summary: Chemical tools for studying cellular signaling cascades; protein engineering; organic synthesis.
Professor, Pharmaceutical Chemistry
Research summary: Protein engineering, reporter design, drug discovery, cellular and animal imaging, protein liquid-liquid phase separation, visualizing subcellular processes and enzyme activities such as protease, kinase and small GTPase.
Associate Professor, Institute for Neurodegenerative Diseases
Research summary: Cryo-electron microscopy and the structure/function of molecular chaperones and AAA+ proteins involved in protein quality control and cell signaling
Professor, Biochemistry & Biophysics
Research summary: Structure and function of cell-surface receptors; communication between macromolecules; mechanisms of transmembrane signaling; drug design.
Sandler Fellow
Research summary: Mechanisms of transmembrane signaling within the immune system
Professor, Cellular & Molecular Pharmacology
Research summary: Covalent inhibitors; Natural product mechanisms of action; Chemoproteomics.
Professor, Pharmaceutical Chemistry & the Cardiovascular Research Institute
Research summary: Design and genetically encode unnatural amino acids for in vivo investigation of cellular signaling and for the development of new biotherapeutics.
Professor, Pharmaceutical Chemistry
Research summary: Small molecule drug discovery; drug mechanisms as they relate to apoptosis and cancer.
Assistant Professor, Laboratory Medicine
Research summary: Quantitative proteomics and new therapy development for blood cancers
Assistant Professor, Cellular & Molecular Pharmacology
Research summary: Bacterial cell wall nanomachines
Associate Professor, Radiology
Research summary: Development of metabolism and microenvironment-targeted imaging methods, to guide intervention and predict response to molecular therapies
Assistant Professor, Pharmaceutical Chemistry
Research summary: Chemical biology and mass spectrometry-based approach to optimizing drug selectivity and studying the innate immune system and blood formation